Dante, a mercenary specializing in demon hunting, is hired as the bodyguard of Patty Lowell, a young orphan who is the heir to a large fortune. He protects her from several demon assassins, which her greedy uncles have sent so that they can keep the money for themselves. The real heiress, having used Patty as a decoy, arrives to claim the fortune, but one of the uncles transforms into an archdemon and kills the others before Dante slays him. The heiress gives Patty part of her inheritance to keep quiet, and she moves in with Dante at his office, Devil May Cry.