Eighteen years ago, a facility is attacked by the Lizard League who fight Omni-Man and Guardians of the Globe members Immortal, War Woman, Aquarius, Black Samson, and Green Ghost. During this invasion, government scientist Dr. Elias Brandyworth disobeys his superior Steven Erickson and leaves with a dying pregnant woman named Polly who gives birth to a powerful metahuman. Brandyworth swaps her child with the stillborn daughter of the Wilkins family so that she could grow up with a normal family as Samantha Eve Wilkins. As a child, Eve was highly knowledgeable about molecules due to her abilities and admitted to a school for scholars, but longed for a normal life. After discovering her transmutation powers, she scares off her only friend and is transferred back to public school for failing class. As she attempts to become a hero, she meets the now-homeless Brandyworth. He reveals her origins as a government project and warns her not to use her powers. She later battles a group of deformed children who were the government's attempts to recreate her. After the children die while battling her, Erickson captures Eve and Brandyworth. He plans to create better weapons with them and the captive Polly. In the ensuing fight, Erickson kills Brandyworth and Polly. Enraged, Eve breaks through the mental barriers that prevented her from transmuting living material and erases Erickson's memories. Eve returns home only to find her parents upset as they intended to celebrate a birthday party. In a mid-credits scene at the Grayson's home, Nolan and Debbie discuss whether or not Mark's powers will manifest. After Debbie says that they will love him, powers or not, Nolan silently rages while contemplating killing them both before being ashamed of his own reaction.